Edinburgh study pinpoints prostate cancer 'growth' gene
Published: 4th Aug 2012 01:13:51
Scientists from Edinburgh University have pinpointed a gene they say could lead to improvements in the diagnosis and treatment of prostate cancer.
The team studied genes that control the formation of the prostate gland and identified one known as Decorin.
The presence of this gene was reduced in tumours compared to normal prostate cells.
The researchers now hope measurement of Decorin levels could become a reliable diagnostic test for prostate cancer.
The study by scientists from the Centre for Reproductive Health was funded by Prostate Cancer UK and the Medical Research Council (MRC).
They believe the gene, Decorin, may play an important role in tumour growth.
Lead researcher, Dr Axel Thomson, said: "We pinpointed which genes were active in embryonic prostate development and compared their behaviour in the development of prostate cancer.
"Through this process we were excited to discover that the presence of one gene - Decorin - was reduced in tumours compared to normal prostate cells.
"This observation suggests that Decorin's normal role may be to slow cancer growth, which is a really exciting possibility.
He added: "If our suspicions are verified then this could mean that, in the future, measurement of Decorin levels could become a reliable diagnostic test for prostate cancer and also help determine how aggressive the disease is."
The finding comes as part of an ongoing research exploring how the environment surrounding cancer cells affects tumour growth.
Dr Kate Holmes, from Prostate Cancer UK, said: "This type of early stage research is vital to help us improve our understanding of prostate cancer development and move towards finding better ways to diagnose and treat the disease.
"Every year 10,000 men lose their lives to the disease, yet we still have very little knowledge of how prostate tumours develop and grow.
"It is vital that more research of this nature is undertaken and supported so that more clues, such as these, can be discovered."
The team's findings are being published in the scientific journal, PLOS ONE.
At 06:59:59 in SportReports suggesting Dustin Johnson has been suspended for failing a drugs test have been denied by the PGA Tour.
At 06:43:59 in SportFor a list of confirmed transfers, check out the transfers page.
At 06:06:21 in HeadlinesTwo American tourists charged with "anti-state" crimes in North Korea have pleaded for the US government to help secure their release.
At 05:39:52 in PoliticsNato needs to rethink its long-term relationship with Russia, which views the alliance as "an adversary", Prime Minister David Cameron has warned.
At 05:38:04 in HeadlinesA massive landslide has buried dozens of homes in Nepal, with four people confirmed dead so far, say police.
At 05:31:22 in HeadlinesGaza's conflict is once again on front pages as the collapse of the latest ceasefire and alleged kidnapping of an Israeli soldier left hopes for peace in tatters.
At 04:58:53 in HeadlinesAn explosion at a factory in eastern China has killed at least 65 people, according to Chinese state media.
At 03:59:13 in HealthA campaign for a baby with Down's Syndrome left with his surrogate Thai mother by an Australian couple has raised over $120,000 (£70,000).
At 03:50:50 in EnglandWhen you cannot afford every thing through your salary income if emergency cash requirement middle of month then consider fast quick payday loans same day services for UK people who want to loans up to 1000 pounds in your bank account less than 15 minutes.When unforeseen expenses crop up at the weekend in your life and you don't have no funds left in your pocket to manage unavoidable excess expenses then it will be difficult to handle them on time. Don't worry! For covering up extra payments at the weekend is probable. Right now you can go for weekend payday loans for bad credit.
At 03:03:37 in WorldBritain is to temporarily close its embassy in the Libyan capital, Tripoli, because of worsening violence.
Harvard CitationBBC News, 2012. Edinburgh study pinpoints prostate cancer 'growth' gene [Online] (Updated 4th Aug 2012)
Available at: http://www.ukwirednews.com/news/1444447/Edinburgh-study-pinpoints-prostate-cancer-growth-gene [Accessed 2nd Aug 2014]
News In Other Categories
Nato needs to rethink its long-term relationship with Russia, which views the alliance as "an adversary", Prime Minister David Cameron has warned.
Two American tourists charged with "anti-state" crimes in North Korea have pleaded for the US government to help secure their release.
A gardener says he feared losing his leg after being bitten by a false widow spider hiding in a Vale of Glamorgan shed.
With the doors to its brand new £1million training centre officially open, one of the UK's leading apprentice training providers, Bristol based S&B Automotive Academy, is showcasing its world-class facilities by launching a series of foreign student exchanges for the first time in its 41-year history. To get a flavour of what life is like as an apprentice in the UK, the Academy hosted 16 apprentice engineers and bus drivers from the G9 Automotive College in Hamburg, Germany, as part of a Europe-wide vocational training initiative called the ‘Leonardo Programme’ with support from the European Social Fund. In a reciprocal arrangement, S&B will be sending nine apprentices to Germany during February 2012 so that they can get an appreciation of life in the automotive industry on the Continent. A further three German exchange groups are being planned for next year. Designed to assist the development of vocational skills and training across Europe, including work placements for trainees, the Leonardo Programme has a budget of €1.75bn, which is helping to encourage UK organisations to work with their counterparts abroad. In what is expected to be another challenging year for employers in the UK automotive sector, S&B’s Chief Executive, Jon Winter, claims that the exchange initiative will bring many benefits to the Academy and its apprentices: “In a world of global automotive brands, it’s important for our learners to understand the international context of the industry they have chosen to make their career. This new exchange programme will enable apprentices and Academy staff alike to achieve a better understanding of the challenges and opportunities within the automotive arena in Europe. With the Academy’s influence also extending to the USA and Asia, there’s every possibility that this initiative could move further afield in the future.” Continued Winter: “The need for skilled technicians across the world is on the increase and we actively encourage our apprentices to look at broader horizons during their training. Many of them have already learned the phrase ‘Vorsprung durch Gelehrtheit’, quite simply, ‘Advancement through learning.” In the 2010/11 academic year, S&B doubled the number of successful Apprenticeships over the previous year with some 350 apprentices graduating from the Academy. At the same time, achievement levels reached an all-time high with an overall success rate of 85%. For those learners on the Advanced Apprenticeship three-year programme, success rates were even higher, at over 98%. PHOTO CAPTION: As part of their exchange visit, S&B Automotive Academy arranged for the German apprentices to visit Hampshire bus operator, Bluestar, at its Barton Park depot. The students are pictured with S&B’s Andy West (3rd right) and Steve Prewett, Bluestar’s Area Engineering Manager (2nd right). Ends http://www.sandbaa.com
Reports suggesting Dustin Johnson has been suspended for failing a drugs test have been denied by the PGA Tour.
The Uber taxi app is "competing unfairly" with London's black cabs, senior Labour MP Margaret Hodge says.